021-51111890
购物车（）
sales@molnova.cn
FR194738 free base
CAS No. 204067-45-8
FR194738 free base ( —— )
产品货号. M26220 CAS No. 204067-45-8
FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥4026 | 有现货 |
|
| 10MG | ￥5856 | 有现货 |
|
| 25MG | ￥9153 | 有现货 |
|
| 50MG | ￥12312 | 有现货 |
|
| 100MG | ￥16038 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称FR194738 free base
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.
-
产品描述FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. FR194738 free base is a squalene epoxidase inhibitor.(In Vitro):FR194738 free base potently inhibits squalene epoxidase in HepG2 cell homogenate and liver microsomes in dogs and rats. FR194738 free base inhibits hamster liver microsomal squalene epoxidase activity in a concentration-dependent manner with an IC50 of 14 nM. In intact HepG2 cells, FR194738 free base inhibits the incorporation of [14C]acetate into free cholesterol and cholesteryl ester in a concentration-dependent manner(IC50s = 4.9 and 8.0 nM).?FR194738 free base induces intracellular [14C]squalene accumulation and increases the incorporation of [14C]acetate into squalene.(In Vivo):FR194738 free base reduces the serum levels of total, non high density lipoprotein and high density lipoprotein cholesterol, and triglyceride.?In hamsters, FR194738 free base(32 mg/kg) increases HMG-CoA reductase activity by 1.3-fold.
-
同义词——
-
通路GPCR/G Protein
-
靶点Antibacterial
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number204067-45-8
-
分子量439.7
-
分子式C27H37NO2S
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESCCN(C\C=C\C#CC(C)(C)C)Cc1cccc(OCC(C)(C)OCc2ccsc2)c1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Wang X, Wang D, Zhou Z, Zhu W. Subacute oral toxicity assessment of benalaxyl in mice based on metabolomics methods. Chemosphere. 2018 Jan;191:373-380.
产品手册
关联产品
-
Roburic acid
Roburic acid and phenethyl-trans-ferulate inhibit COX-1 and COX-2.
-
Relebactam
Relebactam (MK-7655)is a novel β-lactamase inhibitor that inhibited both class A and C β-lactamases in vitro.
-
Bisdionin C
Bisdionin C is a potent inhibitor of GH18 chitinase with an IC50 of 0.2 μM for A. fumigatus ChiB1. Bisdionin C inhibits human macrophage chitotriosidase(HCHT, IC50 = 8.3 μM) and acidic mammalian chitinase (AMCase, IC50 = 3.4 μM).
